4 minute read 22 Jan 2018
Patient and doctor holding hands

How R&D is transforming the oncology market

By

Kristin Pothier

EY Global Head of Life Sciences Strategy

Renowned speaker, workshop leader and writer in the life sciences and healthcare worldwide. Passionate about the business of medicine. Former research scientist. Harvard alum.

4 minute read 22 Jan 2018
Related topics Life sciences Health Aging

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Profits, growing market position and sustainability will require a dynamic organization model that adapts to rapid, real-time changes.

With multiple modalities of care for cancer patients, oncology treatment decision-making has always been complex, but accelerating innovation is driving exponential growth in treatment complexity.

There are more than 650 cancer treatment candidates in late-stage clinical development (Phases II and III). Based on historical success rates, these could lead to the launch of nearly 100 new treatments across roughly 30 clinical indications over the next five to seven years.

Traditional approaches to product development and operational management will no longer ensure success. This strategic transformation of oncology manufacturers requires coordination on three dimensions:

  • Refocused portfolio management
  • Innovative partnership networks
  • Dynamic organizational decision processes

As having the first or best molecule in a class becomes a more short-lived differentiator, pharma companies will need to rethink their approach to market leadership. Market leaders will need a portfolio of complementary mechanisms with a central role in combination regimens across tumor types. Consequently, innovators must balance the need to pursue complementary mechanisms and combination regimens against the greater intensity of investment required to develop and position each molecule.

Traditional approaches to product development and operational management will no longer ensure success.

Creative partnerships with a network of collaborators are also essential in this new marketplace, particularly given the advent of immuno-oncology and targeted therapies, both of which are exponentially increasing competitive intensity and the number of possible therapeutic combinations.

Development and partnering decisions, especially regarding combination regimens and companion diagnostics, will require substantial commercial and clinical involvement, coordinated globally across brands and tumor types. To manage increasingly complex collaboration networks, organizations will also need to revisit how they are structured and resourced to effectively identify, evaluate, transact and manage these alliances.

Transformation will require a more dynamic organization model that enables rapid evaluation of strategic options and real-time decision-making. To make more responsive decisions for their programs, brands and deals, functional teams across R&D, commercial and business development need greater coordination with predefined decision criteria and real-time competitive intelligence.

Businesses that move confidently to adapt to and capitalize on the rapid disruption of the oncology market will have a strong competitive advantage and are more likely to achieve a profitable and growing market position, and a sustainable position in the future oncology ecosystem.

 

This excerpt is from the article “Oncology Disruption Demands Strategic Transformation” by Troy Norris, former Executive Director, Parthenon-EY; Keyuri Shah, Vice President, Parthenon-EY; and Kristin Pothier, Global Head of Life Sciences and Managing Director, Parthenon-EY, published in the October 2017 issue of In Vivo.

Summary

Businesses that adapt to the rapid disruption of the oncology market will have a sustainable position in the future oncology ecosystem.

About this article

By

Kristin Pothier

EY Global Head of Life Sciences Strategy

Renowned speaker, workshop leader and writer in the life sciences and healthcare worldwide. Passionate about the business of medicine. Former research scientist. Harvard alum.

Related topics Life sciences Health Aging