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Such was the case with IntraBio, a US-based biopharmaceutical startup developing novel treatments for rare and common neurological disorders. Headquartered in Austin, Texas, IntraBio was on the verge of a major milestone: the launch of its first commercial product, with plans for rapid expansion and a possible IPO on the horizon. In September 2024, its drug Aqneursa (levacetylleucine) received U.S. Food and Drug administration (FDA) approval for the treatment of Niemann-Pick type C (NPC), a devastating, fatal neurological disease often described as “childhood Alzheimer’s.”
Following FDA approval, IntraBio’s last private financing round catapulted the company into a billion-dollar valuation. But that success was built on a foundation of lean operations. For the past eight years, IntraBio focused its limited resources on R&D and regulatory milestones. “We were able to fund the company through private investors and family offices rather than relying on traditional venture capital,” said Dave McLennan, IntraBio’s Vice President of Finance. “Because we kept costs low, we minimized dilution and maintained founder control, which was a tremendous advantage at that stage of the company’s development.”